MyTron™ Low Binding Magnetic Beads Streptavidin are streptavidin-conjugated rod-shaped nanobeads (particle size <30 nm) engineered specifically for antibody discovery and high-throughput screening. In liquid-phase biopanning workflows such as phage display, yeast display and mRNA display, this product enables capture of targets in their free solution conformation using biotinylated antigens, circumventing epitope masking and conformational distortion caused by conventional solid-phase immobilization.
Its core advantages are as follows: the anti-biofouling coating confers extremely low non-specific binding, markedly reducing false positive rates and cutting down ineffective panning rounds; the <30 nm rod-shaped nanostructure delivers ultra-high specific surface area and homogeneous dispersibility, maximizing collision efficiency between library clones and targets and improving the capture probability of rare high-affinity clones. Magnetic separation takes <1 min, enabling rapid and gentle washing and elution procedures to maximally preserve weak-binding / highly specific clones and prevent loss of diversity arising from overly stringent conditions.
The entire workflow is compatible with automated liquid handling workstations, allowing seamless transition from efficient enrichment at picomolar (pM) antigen concentrations to monoclonal identification, thereby accelerating antibody discovery pipelines.
